PRKD3 and VAMP2

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PRKD3	VAMP2
Description		protein kinase D3	vesicle associated membrane protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding
	Biological Process	Protein Phosphorylation Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Protein Kinase D Signaling	Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Neurotransmitter Secretion Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell
Pathways		Sphingolipid de novo biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Botulinum Toxin Type B
Diseases
GWAS		Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 24292274) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 23974872) Systolic blood pressure ( 28135244 27841878)	Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		12 interacting genes: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2	47 interacting genes: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21
Entrez ID		23683	6844
HPRD ID		06151	01717
Ensembl ID		ENSG00000115825	ENSG00000220205
Uniprot IDs		O94806	F8WCA0 P63027
PDB IDs		2D9Z	3FIE 3FII 3RK2 3RK3 3RL0
Enriched GO Terms of Interacting Partners?
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