SKA2 and SKA1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		SKA2	SKA1
Description		spindle and kinetochore associated complex subunit 2	spindle and kinetochore associated complex subunit 1
Image
GO Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule Microtubule Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Large HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231)
Interacting Genes		6 interacting genes: HMOX2 IFT57 PRKD3 RALY SKA1 SPC24	13 interacting genes: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SKA3 SNAPIN SPC24 SSC5D SYCE1
Entrez ID		348235	220134
HPRD ID		13306	12689
Ensembl ID		ENSG00000182628	ENSG00000154839
Uniprot IDs		J3KSP0 Q8WVK7	A0A024R294 Q96BD8
PDB IDs		4AJ5	4AJ5 4C9Y 4CA0
Enriched GO Terms of Interacting Partners?
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