IGBP1 and PPP4C

Data Source:
HPRD (two hybrid)

		IGBP1	PPP4C
Description		immunoglobulin binding protein 1	protein phosphatase 4 catalytic subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Protein Phosphatase 4 Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation B Cell Activation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Microtubule-based Movement Response To Interleukin-1	Protein Dephosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination NIK/NF-kappaB Signaling
Pathways			Processing of DNA double-strand break ends
Drugs
Diseases		Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS			Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX	21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA RPA2 TIPRL TK1 TMSB4X TP53 TRAF6
Entrez ID		3476	5531
HPRD ID		02140	03615
Ensembl ID		ENSG00000089289	ENSG00000149923
Uniprot IDs		P78318	A0A024R625 P60510
PDB IDs		4IYP
Enriched GO Terms of Interacting Partners?
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