H3C15 and ANP32A

Data Source:
BioGRID (unspecified method)

		H3C15	ANP32A
Description		H3 clustered histone 15	acidic nuclear phosphoprotein 32 family member A
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GO Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Histone Binding
	Biological Process	RDNA Heterochromatin Assembly Chromatin Organization Nucleosome Assembly Blood Coagulation Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA	Nucleocytoplasmic Transport Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MRNA Stability
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production	HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS			Esophageal cancer ( 21642993)
Interacting Genes		18 interacting genes: ANP32A CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 KDM5A KDM5C LALBA MECP2 NASP PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UBR7 UHRF1	29 interacting genes: ADAP1 APEX1 ATXN1 AXIN1 CHAF1A E4F1 ELAVL1 H2AC20 H2BC21 H3-4 H3C1 H3C15 H4-16 H4C1 HSPB3 KPNA1 KPNA5 KPNA6 LHX3 MAP1B NSFL1C PCBP1 PGR PPARG PTPRC SET TAF1A THRB XPO1
Entrez ID		333932	8125
HPRD ID			09014
Ensembl ID		ENSG00000203852	ENSG00000140350
Uniprot IDs		Q71DI3	A0A384P5U2 P39687
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA	2JE0 2JE1 4XOS
Enriched GO Terms of Interacting Partners?
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