APLP1 and PNP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APLP1	PNP
Description		amyloid beta precursor like protein 1	purine nucleoside phosphorylase
Image
GO Annotations	Cellular Component	Basement Membrane Nucleoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Protein Binding Phosphate Ion Binding Identical Protein Binding
	Biological Process	Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Animal Organ Morphogenesis Extracellular Matrix Organization Forebrain Development Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleotide Biosynthetic Process Interleukin-2 Production Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Neutrophil Degranulation Positive Regulation Of Alpha-beta T Cell Differentiation
Pathways			Neutrophil degranulation Purine salvage Purine catabolism
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-deazainosine Guanosine Ribose-1-Phosphate (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium 3'-deoxyguanosine (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE Forodesine
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Severe influenza A (H1N1) infection ( 26379185)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)
Interacting Genes		43 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 ERBB2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	11 interacting genes: APLP1 CCDC90B LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1
Entrez ID		333	4860
HPRD ID		00102	01247
Ensembl ID		ENSG00000105290	ENSG00000198805
Uniprot IDs		P51693	P00491 V9HWH6
PDB IDs		3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA	1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF
Enriched GO Terms of Interacting Partners?
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