AIRE and PTTG1IP

Data Source:
BioGRID (biochemical)

		AIRE	PTTG1IP
Description		autoimmune regulator	PTTG1 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body	Nucleus Nucleoplasm Cytoplasm Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity	P53 Binding Molecular_function Protein Binding
	Biological Process	Peripheral T Cell Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cellular Protein Catabolic Process
Pathways
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114)	Ankylosing spondylitis ( 30946743) Apolipoprotein A1 levels ( 32203549) Delirium ( 29631748) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)
Interacting Genes		5 interacting genes: CREBBP DAXX H2BC21 H3C1 UBAC1	11 interacting genes: AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14
Entrez ID		326	754
HPRD ID		06301	04807
Ensembl ID		ENSG00000160224	ENSG00000183255
Uniprot IDs		O43918	B4DPZ0 P53801
PDB IDs		1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?
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