NR4A1 and ABCC6

Data Source:
BioGRID (two hybrid)

		NR4A1	ABCC6
Description		nuclear receptor subfamily 4 group A member 1	ATP binding cassette subfamily C member 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Nuclear Membrane	Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Glucocorticoid Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATPase Activity Inorganic Diphosphate Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus	Drug Transmembrane Transport Visual Perception ATP Transport Inorganic Diphosphate Transport Response To Drug Xenobiotic Transport Transmembrane Transport Leukotriene Transport Anion Transmembrane Transport
Pathways		AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer	ABC-family proteins mediated transport Defective ABCC6 causes PXE
Drugs			ATP
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)
Interacting Genes		87 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1
Entrez ID		3164	368
HPRD ID		00744	04453
Ensembl ID		ENSG00000123358	ENSG00000091262
Uniprot IDs		A0A024R126 F5GXF0 P22736 Q6ZMM6	O95255
PDB IDs		2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1	6BZR 6BZS 6NLO 6P7F
Enriched GO Terms of Interacting Partners?
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