ABCC6 and AK2

Data Source:
BioGRID (two hybrid)

		ABCC6	AK2
Description		ATP binding cassette subfamily C member 6	adenylate kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Extracellular Exosome Sperm Mitochondrial Sheath
	Molecular Function	Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATPase Activity Inorganic Diphosphate Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity	Adenylate Kinase Activity Protein Binding ATP Binding
	Biological Process	Drug Transmembrane Transport Visual Perception ATP Transport Inorganic Diphosphate Transport Response To Drug Xenobiotic Transport Transmembrane Transport Leukotriene Transport Anion Transmembrane Transport	ADP Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Phosphorylation AMP Metabolic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation
Pathways		ABC-family proteins mediated transport Defective ABCC6 causes PXE	Interconversion of nucleotide di- and triphosphates
Drugs		ATP	Bis(Adenosine)-5'-Pentaphosphate Imidazole
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1	4 interacting genes: ABCC5 ABCC6 SHBG TRIM54
Entrez ID		368	204
HPRD ID		04453	00047
Ensembl ID		ENSG00000091262	ENSG00000004455
Uniprot IDs		O95255	A0A140VK93 F8VY04 F8W1A4 G3V213 P54819
PDB IDs		6BZR 6BZS 6NLO 6P7F	2C9Y
Enriched GO Terms of Interacting Partners?
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