HK3 and PTGDS

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HK3	PTGDS
Description		hexokinase 3	prostaglandin D2 synthase
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Small Molecule Binding
	Biological Process	Cellular Glucose Homeostasis Fructose 6-phosphate Metabolic Process Glycolytic Process Neutrophil Degranulation Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis	Prostaglandin Biosynthetic Process Cyclooxygenase Pathway Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		Neutrophil degranulation Glycolysis	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation
Drugs			Vitamin A
Diseases
GWAS		Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Beta-trace protein levels ( 23328707) Blood protein levels ( 29875488) Corneal structure ( 23291589)
Interacting Genes		10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17	22 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2
Entrez ID		3101	5730
HPRD ID		00806	08904
Ensembl ID		ENSG00000160883	ENSG00000107317
Uniprot IDs		A0A024R7R1 P52790	A0A024R8G3 P41222
PDB IDs		3HM8	2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9
Enriched GO Terms of Interacting Partners?
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