ACACA and PRKAG1

Data Source:
BioGRID (enzymatic study)

		ACACA	PRKAG1
Description		acetyl-CoA carboxylase alpha	protein kinase AMP-activated non-catalytic subunit gamma 1
Image
GO Annotations	Cellular Component	Fibrillar Center Cytosol Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex
	Molecular Function	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Cellular Response To Glucose Starvation Positive Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Biotin	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Ovarian cancer ( 23535730)	Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		11 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 PRKAA1 PRKAA2 PRKAB1 PRKAG1	28 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1 TNFAIP1
Entrez ID		31	5571
HPRD ID		01938	04118
Ensembl ID		ENSG00000278540	ENSG00000181929
Uniprot IDs		A0A024R0Y2 Q13085 Q7Z5W8	A0A024R125 P54619
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?