HDGF and TRAF7

Data Source:
BioGRID (affinity chromatography technology)

		HDGF	TRAF7
Description		heparin binding growth factor	TNF receptor associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Collagen-containing Extracellular Matrix	Ubiquitin Ligase Complex Nucleolus Plasma Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Transcription Corepressor Binding Double-stranded DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity RNA Binding Growth Factor Activity Heparin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Signal Transduction IRE1-mediated Unfolded Protein Response Cellular Response To Interleukin-7	Ribosomal Large Subunit Assembly Activation Of MAPKKK Activity Apoptotic Process Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Signaling Pathway
Pathways		XBP1(S) activates chaperone genes	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)	Diastolic blood pressure ( 30578418) Height ( 28552196) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		5 interacting genes: APP GPR37 JUN SMAD4 XBP1	12 interacting genes: CDC42 CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6
Entrez ID		3068	84231
HPRD ID		02079	06977
Ensembl ID		ENSG00000143321	ENSG00000131653
Uniprot IDs		A0A384NPW1 A8K8G0 B7Z958 P51858	B3KQY7 Q6Q0C0
PDB IDs		1RI0 2NLU
Enriched GO Terms of Interacting Partners?
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