DNMT3L and FOSL2

Data Source:
BioGRID (pull down)

		DNMT3L	FOSL2
Description		DNA methyltransferase 3 like	FOS like 2, AP-1 transcription factor subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Regulation Of Catalytic Activity Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation	Keratinocyte Development Regulation Of Transcription By RNA Polymerase II Cell Death Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation
Pathways		DNA methylation
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Blond vs. brown/black hair color ( 30531825) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 28135244 30578418) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 1 diabetes ( 21980299)
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	22 interacting genes: ATF2 BACH2 CREB5 CYTH1 DDIT3 DNAJA3 DNMT3L EP300 FHL3 GMCL1 GOPC JUN JUNB JUND LHX8 LRIF1 LUZP4 MEOX2 NME7 POLR2G SRA1 TRAF1
Entrez ID		29947	2355
HPRD ID		09417	03343
Ensembl ID		ENSG00000142182	ENSG00000075426
Uniprot IDs		Q9UJW3	P15408 Q9H5M2
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J
Enriched GO Terms of Interacting Partners?
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