DNMT3L and KLF12

Data Source:
BioGRID (pull down)

		DNMT3L	KLF12
Description		DNA methyltransferase 3 like	Kruppel like factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol ESC/E(Z) Complex	Chromatin Nucleoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Regulation Of Catalytic Activity Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		DNA methylation
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Bronchopulmonary dysplasia ( 23897914) Colorectal cancer ( 30529582) Craniofacial microsomia ( 26853712) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Energy expenditure ( 30071075) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549 28869591) Heschl's gyrus morphology ( 25130324) Lean body mass ( 28724990) Long QT syndrome ( 32429735) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Neurofibrillary tangles ( 25188341) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Phospholipid levels (plasma) ( 22359512) Photic sneeze reflex ( 27182965) QRS duration ( 30679814 27577874 30012220 21076409 27659466) QT interval ( 24952745 29874175) Refractive error ( 32231278) Systemic lupus erythematosus ( 19838195) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438) Waist-to-hip ratio adjusted for body mass index ( 27195708) White blood cell count ( 32888494)
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	7 interacting genes: APP CTBP1 DNMT3L EHMT2 FHL2 FHL3 THAP1
Entrez ID		29947	11278
HPRD ID		09417	06336
Ensembl ID		ENSG00000142182	ENSG00000118922
Uniprot IDs		Q9UJW3	Q8WWI3 Q9Y4X4
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J
Enriched GO Terms of Interacting Partners?
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