NOTCH2 and MAML1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NOTCH2	MAML1
Description		notch receptor 2	mastermind like transcriptional coactivator 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Stem Cell Population Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Growth Rate Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Proximal Tubule Development Glomerular Visceral Epithelial Cell Development Glomerular Capillary Formation Hepatocyte Proliferation Cholangiocyte Proliferation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Osteoclast Development	Atrioventricular Node Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Atrioventricular Node Cell Development
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases		Alagille syndrome Type II diabetes mellitus Hajdu-Cheney syndrome
GWAS		Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 18372903 30054458 30297969)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 27863252) Resting heart rate ( 24680774) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SMAD1 ST14	11 interacting genes: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ TP53
Entrez ID		4853	9794
HPRD ID		02606	05665
Ensembl ID		ENSG00000134250	ENSG00000161021
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q92585
PDB IDs		2OO4 5MWB	2F8X 3NBN 3V79 6SMV
Enriched GO Terms of Interacting Partners?
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