GTF2H1 and EAF1

Data Source:
BioGRID (two hybrid)

		GTF2H1	EAF1
Description		general transcription factor IIH subunit 1	ELL associated factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	Chromatin Binding Protein Binding Thyroid Hormone Receptor Binding	Transcription Elongation Regulator Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Hormone-mediated Signaling Pathway Nucleotide-excision Repair, DNA Incision Positive Regulation Of Transcription, DNA-templated Phosphorylation Of RNA Polymerase II C-terminal Domain Global Genome Nucleotide-excision Repair	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 28240269) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944) Survival in pancreatic cancer ( 28470677)
Interacting Genes		47 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 PIK3R1 PLCG1 POLR2A POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1	53 interacting genes: AP2M1 APP ARID4B BEND7 BHLHB9 CCDC150 CCDC33 CEP70 CEP76 DNTTIP1 DPPA4 ELL ELL2 ELL3 FAM228A GADD45GIP1 GAS8 GCSAML GOLGA6L9 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620
Entrez ID		2965	85403
HPRD ID		01807	12209
Ensembl ID		ENSG00000110768	ENSG00000144597
Uniprot IDs		A0A384MTQ8 P32780	Q96JC9
PDB IDs		1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M
Enriched GO Terms of Interacting Partners?
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