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NLRP3
Description
NLR family pyrin domain containing 3
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
NLRP3 Inflammasome Complex
Molecular Function
Protein Binding
ATP Binding
Transcription Factor Binding
Identical Protein Binding
Peptidoglycan Binding
Sequence-specific DNA Binding
Biological Process
Leukocyte Migration Involved In Inflammatory Response
Negative Regulation Of Acute Inflammatory Response
Positive Regulation Of Type 2 Immune Response
Apoptotic Process
Defense Response
Inflammatory Response
Signal Transduction
Detection Of Biotic Stimulus
Response To Organic Cyclic Compound
Protein Deubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Response To Ethanol
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Lipopolysaccharide
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways
Metalloprotease DUBs
The NLRP3 inflammasome
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
Drugs
Diseases
Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS
C-reactive protein levels (
30388399
21300955
)
Fibrinogen (
20031576
23969696
)
Fibrinogen levels (
28107422
26561523
)
Granulocyte count (
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
)
Red cell distribution width (
32888494
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Waist circumference adjusted for body mass index (
25673412
)
White blood cell count (
32888494
27863252
)
Word reading (
23738518
)
Interacting Genes
10 interacting genes:
ATP1B3
CARD8
CUL1
FAF1
FBXL2
PGM1
PYCARD
STAMBP
TRIM31
VDR
Entrez ID
114548
HPRD ID
05915
Ensembl ID
ENSG00000162711
Uniprot IDs
Q96P20
PDB IDs
2NAQ
3QF2
6NPY
Enriched GO Terms of Interacting Partners
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