NLRP3 and ATP1B3

Data Source:
BioGRID (two hybrid)

		NLRP3	ATP1B3
Description		NLR family pyrin domain containing 3	ATPase Na+/K+ transporting subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Sperm Flagellum Melanosome Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Response To Organic Cyclic Compound Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 2 Cell Cytokine Production	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Stabilization Leukocyte Migration Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494 27863252) Word reading ( 23738518)	Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 27841878) Red cell distribution width ( 32888494 27863252 28957414) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD STAMBP TRIM31 VDR	13 interacting genes: BAALC BARD1 BRCA1 CTXN3 NLRP3 PAXIP1 PEA15 SMAGP STOM TMEM98 TRIM14 UPF2 USP4
Entrez ID		114548	483
HPRD ID		05915	03521
Ensembl ID		ENSG00000162711	ENSG00000069849
Uniprot IDs		Q96P20	P54709
PDB IDs		2NAQ 3QF2 6NPY
Enriched GO Terms of Interacting Partners?
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