REM1 and CACNB4

Data Source:
HPRD (in vivo)

		REM1	CACNB4
Description		RRAD and GEM like GTPase 1	calcium voltage-gated channel auxiliary subunit beta 4
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GO Annotations	Cellular Component	Plasma Membrane	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	GTPase Activity Calcium Channel Regulator Activity Calmodulin Binding GTP Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Signal Transduction Negative Regulation Of High Voltage-gated Calcium Channel Activity	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		7 interacting genes: CACNB1 CACNB2 CACNB4 YWHAE YWHAH YWHAQ YWHAZ	12 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		28954	785
HPRD ID		15237	09057
Ensembl ID		ENSG00000088320	ENSG00000182389
Uniprot IDs		O75628	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305
PDB IDs		2NZJ	2D46
Enriched GO Terms of Interacting Partners?
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