ZDHHC3 and GABRG2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ZDHHC3	GABRG2
Description		zinc finger DHHC-type palmitoyltransferase 3	gamma-aminobutyric acid type A receptor subunit gamma2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Axon Cytoplasmic Vesicle Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Targeting To Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Phosphopantetheinylation Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Positive Regulation Of Synaptic Transmission, GABAergic TRAIL-activated Apoptotic Signaling Pathway Lipoprotein Localization To Membrane Protein Localization To Plasma Membrane Positive Regulation Of Receptor Localization To Synapse Protein Localization To Photoreceptor Outer Segment	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways			Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Acamprosate Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol Benzodiazepine Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2â€²-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Depressive symptom improvement ( 30468137)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Nicotine dependence symptom count ( 25555482) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		6 interacting genes: EWSR1 GABRG2 GPR35 NEDD4L SMAD1 UBQLN4	7 interacting genes: DRD5 GABARAP GABRA2 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		51304	2566
HPRD ID		15718	00663
Ensembl ID		ENSG00000163812	ENSG00000113327
Uniprot IDs		F8W6M3 Q9NYG2	P18507
PDB IDs			6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40
Enriched GO Terms of Interacting Partners?
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