GP1BA and SELP

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		GP1BA	SELP
Description		glycoprotein Ib platelet subunit alpha	selectin P
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Regulation Of Megakaryocyte Differentiation Thrombin-activated Receptor Signaling Pathway Platelet Aggregation	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Blood protein levels ( 30072576 29875488) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Interacting Genes		17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		2811	6403
HPRD ID		01976	01433
Ensembl ID		ENSG00000185245	ENSG00000174175
Uniprot IDs		L7UYB8 P07359	A0A024R8Y9 P16109 Q5R341 Q6NUL9
PDB IDs		1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6	1FSB 1G1Q 1G1R 1G1S 1HES 1KJD
Enriched GO Terms of Interacting Partners?
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