GNAO1 and RGS1

Data Source:
HPRD (in vivo, two hybrid)

		GNAO1	RGS1
Description		G protein subunit alpha o1	regulator of G protein signaling 1
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GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Celiac disease ( 22057235 20190752 30572963 18311140) Multiple sclerosis ( 24076602 21833088 27386562) Systemic lupus erythematosus ( 33536424 28714469)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	9 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 TSC22D1 UTP14A
Entrez ID		2775	5996
HPRD ID		00757	15968
Ensembl ID		ENSG00000087258	ENSG00000090104
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q08116
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ	2BV1 2GTP
Enriched GO Terms of Interacting Partners?
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