GNAO1 and GRM6

Data Source:
HPRD (in vivo)

		GNAO1	GRM6
Description		G protein subunit alpha o1	glutamate metabotropic receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Dendrite New Growing Cell Tip Synapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Homodimerization Activity
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Detection Of Visible Light Detection Of Light Stimulus Involved In Visual Perception Regulation Of Synaptic Transmission, Glutamatergic Retina Development In Camera-type Eye Positive Regulation Of Calcium Ion Import
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Parent of origin effect on receptive language ability (paternal) ( 32635940) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	2 interacting genes: CLK1 GNAO1
Entrez ID		2775	2916
HPRD ID		00757	04975
Ensembl ID		ENSG00000087258	ENSG00000113262
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	O15303
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ
Enriched GO Terms of Interacting Partners?
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