GNAI2 and P2RY12

Data Source:
HPRD (in vivo)

		GNAI2	P2RY12
Description		G protein subunit alpha i2	purinergic receptor P2Y12
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Midbody Cell Body Membrane Raft Synapse Extracellular Exosome Extracellular Vesicle	Mitochondrion Plasma Membrane Caveola External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane Intrinsic Component Of Membrane Cell Projection Membrane Cell Body Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled ADP Receptor Activity Guanyl-nucleotide Exchange Factor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Protein Folding Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein Tyrosine Phosphatase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	G Protein-coupled Adenosine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Hemostasis Negative Regulation Of Norepinephrine Secretion Calcium-mediated Signaling Cytosolic Calcium Signaling Involved In Initiation Of Cell Movement In Glial-mediated Radial Cell Migration Cell Projection Organization Lamellipodium Assembly Positive Regulation Of Integrin Activation By Cell Surface Receptor Linked Signal Transduction Positive Regulation Of Cell Adhesion Mediated By Integrin Calcium-mediated Signaling Using Extracellular Calcium Source G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Ion Transport Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Cell Differentiation Response To Axon Injury Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Regulation Of Calcium Ion Transport Platelet Aggregation Calcium Ion Transmembrane Transport Cellular Response To ATP Potassium Ion Transmembrane Transport Visual System Development Positive Regulation Of Ruffle Assembly Microglial Cell Migration Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	ADP signalling through P2Y purinoceptor 12 P2Y receptors G alpha (i) signalling events
Drugs			Ticlopidine Treprostinil Clopidogrel Promethazine Epoprostenol Regrelor Prasugrel Elinogrel Cangrelor Ticagrelor
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Diverticular disease ( 30177863)
Interacting Genes		64 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	1 interacting genes: GNAI2
Entrez ID		2771	64805
HPRD ID		00764	02743
Ensembl ID		ENSG00000114353	ENSG00000169313
Uniprot IDs		B3KP24 B3KX51 P04899	A8K7T1 Q9H244
PDB IDs		6D9H	1T78 1VZ1 1Y9C 4NTJ 4PXZ 4PY0
Enriched GO Terms of Interacting Partners?
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