GNAI2 and EDNRA

Data Source:
HPRD (in vivo)

		GNAI2	EDNRA
Description		G protein subunit alpha i2	endothelin receptor type A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Midbody Cell Body Membrane Raft Synapse Extracellular Exosome Extracellular Vesicle	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Protein Folding Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein Tyrosine Phosphatase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Regulation Of Glucose Transmembrane Transport Neural Crest Cell Development Artery Smooth Muscle Contraction Vasoconstriction Enteric Nervous System Development Head Development Endothelin Receptor Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Ischemic stroke (large artery atherosclerosis) ( 29531354) Lead levels ( 26025379) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878)
Interacting Genes		64 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2771	1909
HPRD ID		00764	00571
Ensembl ID		ENSG00000114353	ENSG00000151617
Uniprot IDs		B3KP24 B3KX51 P04899	P25101
PDB IDs		6D9H
Enriched GO Terms of Interacting Partners?
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