ITGA1 and MATN1

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ITGA1	MATN1
Description		integrin subunit alpha 1	matrilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Exosome	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis	Growth Plate Cartilage Chondrocyte Morphogenesis Extracellular Matrix Organization Regulation Of Bone Mineralization Protein-containing Complex Assembly
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	ECM proteoglycans
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein B levels ( 32203549) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein level ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 30130595 32499647 30718926 29926116)	Broad depression or schizophrenia ( 30626913) Low high density lipoprotein cholesterol levels ( 26879886) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 30285260)
Interacting Genes		10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1	5 interacting genes: COL2A1 ITGA1 MATN2 MATN3 MATN4
Entrez ID		3672	4146
HPRD ID		01892	00276
Ensembl ID		ENSG00000213949	ENSG00000162510
Uniprot IDs		P56199	P21941
PDB IDs		1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
Enriched GO Terms of Interacting Partners?
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