ZNF638 and WWP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF638	WWP1
Description		zinc finger protein 638	WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Double-stranded DNA Binding RNA Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	RNA Splicing	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell
Pathways		Transcriptional regulation of white adipocyte differentiation	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Heel bone mineral density ( 30598549 28869591) Height ( 25282103 25429064 31562340 23456168) Hip circumference adjusted for BMI ( 28552196) Intelligence ( 28530673) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878 30578418) QRS interval (sulfonylurea treatment interaction) ( 27958378) Reaction time ( 29844566) Testicular germ cell tumor ( 28604728)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		14 interacting genes: CALCOCO2 CCDC85B EFEMP2 FHL2 HOOK2 KIFBP KRT15 KRT19 KRTAP4-12 NELFCD PLSCR1 SPP1 SUMO2 WWP1	55 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		27332	11059
HPRD ID		11736	03811
Ensembl ID		ENSG00000075292	ENSG00000123124
Uniprot IDs		A8K583 Q14966	Q9H0M0
PDB IDs		6SXW	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y
Enriched GO Terms of Interacting Partners?
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