WWP1 and CLCN5

Data Source:
HPRD (in vitro)

		WWP1	CLCN5
Description		WW domain containing E3 ubiquitin protein ligase 1	chloride voltage-gated channel 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Solute:proton Antiporter Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Endocytosis Excretion Ion Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Estimated glomerular filtration rate ( 31152163)	Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)
Interacting Genes		55 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	4 interacting genes: CFL1 MAGI1 WWP1 WWP2
Entrez ID		11059	1184
HPRD ID		03811	02053
Ensembl ID		ENSG00000123124	ENSG00000171365
Uniprot IDs		Q9H0M0	A8K4H5 B3KRR2 P51795 V9GYG7
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	2J9L 2JA3
Enriched GO Terms of Interacting Partners?
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