WWP1 and MACROH2A2

Data Source:
BioGRID (two hybrid)

		WWP1	MACROH2A2
Description		WW domain containing E3 ubiquitin protein ligase 1	macroH2A.2 histone
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Chromosome, Telomeric Region Chromatin Nucleosome Barr Body Nucleoplasm Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Chromatin Silencing Brain Development Dosage Compensation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)
Interacting Genes		55 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	3 interacting genes: FAM133A H2BC15 WWP1
Entrez ID		11059	55506
HPRD ID		03811	13625
Ensembl ID		ENSG00000123124	ENSG00000099284
Uniprot IDs		Q9H0M0	A0A024QZP6 Q9P0M6
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	2XD7 6FY5
Enriched GO Terms of Interacting Partners?
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