SESN1 and PRDX1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SESN1	PRDX1
Description		sestrin 1	peroxiredoxin 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol TORC2 Complex GATOR2 Complex	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Leucine Binding	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cadherin Binding
	Biological Process	Positive Regulation Of Macroautophagy Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Cellular Response To Leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Cellular Response To Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis
Pathways		Amino acids regulate mTORC1	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 32296059) Birth weight ( 31043758) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)	Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: MIOS PRDX1 WDR24	29 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		27244	5052
HPRD ID		07310	01458
Ensembl ID		ENSG00000080546	ENSG00000117450
Uniprot IDs		Q9Y6P5	A0A384NPQ2 Q06830
PDB IDs			2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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