EPS8 and BCKDK

Data Source:
BioGRID (two hybrid)

		EPS8	BCKDK
Description		epidermal growth factor receptor pathway substrate 8	branched chain keto acid dehydrogenase kinase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity	Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
	Biological Process	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Glucose Metabolic Process Phosphorylation
Pathways			Branched-chain amino acid catabolism
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)
Interacting Genes		61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3	8 interacting genes: APP EPS8 FBXO7 LSM8 NR5A2 SPTA1 STAT3 TRAF4
Entrez ID		2059	10295
HPRD ID		02563	12523
Ensembl ID		ENSG00000151491	ENSG00000103507
Uniprot IDs		B4E3T6 Q12929	A0A024QZA9 O14874
PDB IDs		2E8M
Enriched GO Terms of Interacting Partners?
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