BEX3 and NTRK3

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		BEX3	NTRK3
Description		brain expressed X-linked 3	neurotrophic receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Multicellular Organism Development Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		NADE modulates death signalling	Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs			Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases			Neuroblastoma
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		41 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 ENKD1 FSD2 GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		27018	4916
HPRD ID		02291	01870
Ensembl ID		ENSG00000166681	ENSG00000140538
Uniprot IDs		Q00994	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs		1SA6	1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?
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