FBXW8 and CUL7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FBXW8	CUL7
Description		F-box and WD repeat domain containing 8	cullin 7
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Golgi Organization Cell Population Proliferation Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Labyrinthine Layer Blood Vessel Development Positive Regulation Of Transcription Factor Catabolic Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			3M syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Marginal zone lymphoma or rheumatoid arthritis ( 31407831) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Interacting Genes		6 interacting genes: CUL7 IRS1 MYC RBX1 SKP1 UBE2D3	9 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 UBE2M
Entrez ID		26259	9820
HPRD ID		16427	09901
Ensembl ID		ENSG00000174989	ENSG00000044090
Uniprot IDs		Q8N3Y1	Q14999
PDB IDs			2JNG
Enriched GO Terms of Interacting Partners?
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