FBXW8 and IRS1

  • Data Source:
  • BioGRID (enzymatic study)

FBXW8

IRS1

Description F-box and WD repeat domain containing 8 insulin receptor substrate 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Brain morphology (MOSTest) ( 32665545)
  • Brain structure ( 22504417)
  • Dentate gyrus granule cell layer volume ( 30279459)
  • Dentate gyrus molecular layer volume ( 30279459)
  • HATA volume ( 30279459)
  • Hippocampal subfield CA1 volume ( 30279459)
  • Hippocampal subfield CA3 volume ( 30279459)
  • Hippocampal subfield CA4 volume ( 30279459)
  • Hippocampal tail volume ( 30279459)
  • Marginal zone lymphoma or rheumatoid arthritis ( 31407831)
  • Subiculum volume ( 30279459)
  • Total hippocampal volume ( 30279459)
Interacting Genes 6 interacting genes: CUL7 IRS1 MYC RBX1 SKP1 UBE2D3 79 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TRIM72 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 26259 3667
HPRD ID 16427 00943
Ensembl ID ENSG00000174989 ENSG00000169047
Uniprot IDs Q8N3Y1 P35568
PDB IDs 1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
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