POLDIP2 and ALAS1

Data Source:
BioGRID (two hybrid, two hybrid)

		POLDIP2	ALAS1
Description		DNA polymerase delta interacting protein 2	5'-aminolevulinate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	DNA Binding Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Mitochondrion Morphogenesis Error-free Translesion Synthesis	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		19 interacting genes: AGTRAP ALAS1 APP ASCC2 CHCHD2 CPE DNAAF6 FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1	54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		26073	211
HPRD ID		17874	00505
Ensembl ID		ENSG00000004142	ENSG00000023330
Uniprot IDs		B4DEM9 Q9Y2S7	B4DVA0 P13196 Q5JAM2
PDB IDs		6Z9C
Enriched GO Terms of Interacting Partners?
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