ALAS1 and OXTR

Data Source:
BioGRID (two hybrid)

		ALAS1	OXTR
Description		5'-aminolevulinate synthase 1	oxytocin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Adherens Junction Apical Plasma Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Estrous Cycle Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Vasopressin-like receptors G alpha (q) signalling events
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine	Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3
Entrez ID		211	5021
HPRD ID		00505	01328
Ensembl ID		ENSG00000023330	ENSG00000180914
Uniprot IDs		B4DVA0 P13196 Q5JAM2	B2R9L7 P30559
PDB IDs			6TPK
Enriched GO Terms of Interacting Partners?
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