ALAS1 and CERK

Data Source:
BioGRID (two hybrid)

		ALAS1	CERK
Description		5'-aminolevulinate synthase 1	ceramide kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Magnesium Ion Binding Lipid Kinase Activity Ceramide Kinase Activity NAD+ Kinase Activity Protein Binding ATP Binding Dihydroceramide Kinase Activity
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Phosphorylation Lipid Phosphorylation
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Glycosphingolipid metabolism
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Aseptic loosening in total joint arthroplasty ( 31791832) Triglyceride levels ( 30108155)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	21 interacting genes: ALAS1 APP CRYBA1 CYSRT1 KRT34 KRTAP1-1 KRTAP10-3 KRTAP11-1 KRTAP19-1 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP9-2 MTUS2 NBPF19 NHLRC4 NOTCH2NLA OIP5 PLEKHF2 TRIM42
Entrez ID		211	64781
HPRD ID		00505	09878
Ensembl ID		ENSG00000023330	ENSG00000100422
Uniprot IDs		B4DVA0 P13196 Q5JAM2	A0A024R4U8 Q8TCT0
PDB IDs
Enriched GO Terms of Interacting Partners?
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