APPL1 and ADIPOR2

Data Source:
BioGRID (two hybrid)

		APPL1	ADIPOR2
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	adiponectin receptor 2
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Signaling Receptor Activity Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Protein Phosphorylation Heart Development Female Pregnancy Response To Nutrient Response To Fructose Hormone-mediated Signaling Pathway Negative Regulation Of Gene Expression Response To Amine Fatty Acid Oxidation Negative Regulation Of Cell Growth Response To Lipopolysaccharide Adiponectin-activated Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Response To Drug Glucose Homeostasis Response To Ethanol Positive Regulation Of Glucose Import Vascular Wound Healing Negative Regulation Of Hepatic Stellate Cell Migration Cellular Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Red cell distribution width ( 32888494) Urate levels in lean individuals ( 25811787)
Interacting Genes		64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	3 interacting genes: ADIPOQ APPL1 TMBIM6
Entrez ID		26060	79602
HPRD ID		05053	06403
Ensembl ID		ENSG00000157500	ENSG00000006831
Uniprot IDs		Q9UKG1	Q86V24
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	5LWY 5LX9 5LXA 6KS1
Enriched GO Terms of Interacting Partners?
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