APPL1 and BRWD1

Data Source:
BioGRID (two hybrid)

		APPL1	BRWD1
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	bromodomain and WD repeat domain containing 1
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Molecular_function
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape Interleukin-7-mediated Signaling Pathway
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
Drugs
Diseases
GWAS			Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)
Interacting Genes		64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	12 interacting genes: APP APPL1 CALM1 FNDC3B HDAC7 NRF1 NUTF2 SMARCA4 SMARCD1 STAT3 TRIM55 TRIM63
Entrez ID		26060	54014
HPRD ID		05053	11683
Ensembl ID		ENSG00000157500	ENSG00000185658
Uniprot IDs		Q9UKG1	Q9NSI6
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	3Q2E
Enriched GO Terms of Interacting Partners?
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