APPL1 and RAB21

Data Source:
BioGRID (pull down)

		APPL1	RAB21
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	RAB21, member RAS oncogene family
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Endosome Early Endosome Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Vesicle Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Cleavage Furrow Golgi Cisterna Membrane Synapse Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Axon Cytoplasm
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Intracellular Protein Transport Anterograde Axonal Transport Regulation Of Exocytosis Regulation Of Axon Extension Rab Protein Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Body mass index ( 29273807) General cognitive ability ( 29844566) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	1 interacting genes: APPL1
Entrez ID		26060	23011
HPRD ID		05053	06695
Ensembl ID		ENSG00000157500	ENSG00000080371
Uniprot IDs		Q9UKG1	A0A024RBA9 Q9UL25
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	1YZT 1YZU 1Z08 1Z0I 2OT3
Enriched GO Terms of Interacting Partners?
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