CNTNAP2 and CASK

Data Source:
HPRD (in vitro)

		CNTNAP2	CASK
Description		contactin associated protein 2	calcium/calmodulin dependent serine protein kinase
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Matrix Presynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding Enzyme Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Neurotransmitter Secretion Negative Regulation Of Keratinocyte Proliferation GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways			Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs			Formic acid Fostamatinib
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome	FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Family history of Alzheimer's disease ( 30617256) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) Postprandial triglyceride response ( 32603185) QT interval (drug interaction) ( 23459443) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		11 interacting genes: CASK CNTN2 CPE CTR9 EPB41L3 GORASP2 KCNA2 MACF1 MEOX2 POLR2G ZMIZ1	88 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L C20orf85 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DNAJC5 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE
Entrez ID		26047	8573
HPRD ID		05197	02164
Ensembl ID		ENSG00000174469	ENSG00000147044
Uniprot IDs		A0A090N7T7 B2RCH4 Q9UHC6	A0A2R8Y6F8 A0A2R8YE77 O14936
PDB IDs		5Y4M	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH
Enriched GO Terms of Interacting Partners?
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