CASK and GRIK2

Data Source:
HPRD (in vivo, in vitro)

		CASK	GRIK2
Description		calcium/calmodulin dependent serine protein kinase	glutamate ionotropic receptor kainate type subunit 2
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GO Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Neurotransmitter Secretion Negative Regulation Of Keratinocyte Proliferation GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Negative Regulation Of Cellular Response To Growth Factor Stimulus	Behavioral Fear Response Cellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		Formic acid Fostamatinib	Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS			Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Weight ( 28552196)
Interacting Genes		88 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L C20orf85 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DNAJC5 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE	18 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		8573	2898
HPRD ID		02164	00692
Ensembl ID		ENSG00000147044	ENSG00000164418
Uniprot IDs		A0A2R8Y6F8 A0A2R8YE77 O14936	A8K0H7 Q13002 Q8IY40
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH	3QXM 5CMM
Enriched GO Terms of Interacting Partners?
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