LRP10 and HTRA1

Data Source:
HPRD (two hybrid)

		LRP10	HTRA1
Description		LDL receptor related protein 10	HtrA serine peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Clathrin-coated Pit Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Endocytosis Inner Ear Development	Placenta Development Proteolysis Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis
Pathways		Retinoid metabolism and transport	Degradation of the extracellular matrix
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Neutrophil count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778 33020668) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		23 interacting genes: C16orf92 CISD2 EBP FAM209A GGA3 GJB5 GOLM2 GORAB HTRA1 LMNA MFSD14B MGST3 MRPS18B NOTO PDCD1LG2 PLEKHO1 SLC10A1 SLC14A2 SMIM1 ST6GALNAC6 TMEM179B TMEM237 TMEM243	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		26020	5654
HPRD ID		14311	03725
Ensembl ID		ENSG00000197324	ENSG00000166033
Uniprot IDs		Q7Z4F1	Q92743
PDB IDs			2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?
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