RCHY1 and PRDX4

Data Source:
BioGRID (two hybrid)

		RCHY1	PRDX4
Description		ring finger and CHY zinc finger domain containing 1	peroxiredoxin 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding Thioredoxin Peroxidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		75 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		25898	10549
HPRD ID		07607	05935
Ensembl ID		ENSG00000163743	ENSG00000123131
Uniprot IDs		Q96PM5	Q13162 V9HW63
PDB IDs		2JRJ 2K2C 2K2D	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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