PRDX4 and ALG12

Data Source:
BioGRID (two hybrid)

		PRDX4	ALG12
Description		peroxiredoxin 4	ALG12 alpha-1,6-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol Alpha-1,6-mannosyltransferase
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Protein Folding Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation
Pathways		Neutrophil degranulation	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes ALG12-CDG (CDG-1g)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS			Acne (severe) ( 24927181) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	2 interacting genes: PRDX4 RPL13A
Entrez ID		10549	79087
HPRD ID		05935	06189
Ensembl ID		ENSG00000123131	ENSG00000182858
Uniprot IDs		Q13162 V9HW63	A0A024R4V6 Q9BV10
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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