ZNF473 and AEN

Data Source:
BioGRID (two hybrid)

		ZNF473	AEN
Description		zinc finger protein 473	apoptosis enhancing nuclease
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cajal Body	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Nucleic Acid Binding Exonuclease Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing By Stem-loop Binding And Cleavage Histone MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II	Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		SLBP independent Processing of Histone Pre-mRNAs Generic Transcription Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Diseases
GWAS			Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		21 interacting genes: AEN CLK2 CLK3 DHX57 GPATCH2L KRTAP10-10 KRTAP10-8 KRTAP10-9 LSM11 PRPF31 RBM10 RNPS1 SLBP TRIM41 ZNF202 ZNF250 ZNF408 ZNF497 ZNF792 ZNF837 ZSCAN12	37 interacting genes: AAMP EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473
Entrez ID		25888	64782
HPRD ID		11721	08573
Ensembl ID		ENSG00000142528	ENSG00000181026
Uniprot IDs		A0A024QZI1 B4DY71 F8WEC7 Q8WTR7	Q8WTP8
PDB IDs		2EMB 2EMC 2EME 2EOU 2EOX 2EOY 2EOZ 2YRH 2YRJ 2YSV 2YTD 2YTE 2YTT 2YU5
Enriched GO Terms of Interacting Partners?
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