FBXL2 and NLRP3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		FBXL2	NLRP3
Description		F-box and leucine rich repeat protein 2	NLR family pyrin domain containing 3
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GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication	Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Response To Organic Cyclic Compound Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways			Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Heel bone mineral density ( 30598549) Rostral anterior cingulate cortex volume ( 31530798)	C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494 27863252) Word reading ( 23738518)
Interacting Genes		12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 ITPR3 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1	10 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD STAMBP TRIM31 VDR
Entrez ID		25827	114548
HPRD ID		05736	05915
Ensembl ID		ENSG00000153558	ENSG00000162711
Uniprot IDs		Q9UKC9	Q96P20
PDB IDs		6O60	2NAQ 3QF2 6NPY
Enriched GO Terms of Interacting Partners?
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