NGEF and ATP5F1C

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NGEF	ATP5F1C
Description		neuronal guanine nucleotide exchange factor	ATP synthase F1 subunit gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Growth Cone	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	RNA Binding Protein Binding ATPase Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	G Protein-coupled Receptor Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity	Oxidative Phosphorylation ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs			Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		14 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63	29 interacting genes: APP ATP5F1A ATP5F1B CA12 CCND3 CCT7 CDC42 CHMP2B DPP3 DUX4 EGFR ELOF1 ERCC6 FBXO7 GDPD2 ITIH2 MED15 MEOX2 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTEN PTN SERPINA1 ZNF337
Entrez ID		25791	509
HPRD ID		10442	00156
Ensembl ID		ENSG00000066248	ENSG00000165629
Uniprot IDs		B4DDI2 Q8N5V2	B4DL14 P36542 Q8TAS0
PDB IDs
Enriched GO Terms of Interacting Partners?
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