ATP5F1C and CHMP2B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATP5F1C	CHMP2B
Description		ATP synthase F1 subunit gamma	charged multivesicular body protein 2B
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane	ESCRT III Complex Cytoplasm Lysosome Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding ATPase Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Protein Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Oxidative Phosphorylation ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport	Autophagy Nucleus Organization Endosome Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Cognition Multivesicular Body-lysosome Fusion Midbody Abscission Neuron Cellular Homeostasis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell ESCRT III Complex Disassembly
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS			Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		29 interacting genes: APP ATP5F1A ATP5F1B CA12 CCND3 CCT7 CDC42 CHMP2B DPP3 DUX4 EGFR ELOF1 ERCC6 FBXO7 GDPD2 ITIH2 MED15 MEOX2 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTEN PTN SERPINA1 ZNF337	12 interacting genes: ATP5F1C CENPF CHMP3 DPY30 FBXO7 MALSU1 PHGDH PNMA1 TERF2IP TRAF2 USP54 USP8
Entrez ID		509	25978
HPRD ID		00156	13174
Ensembl ID		ENSG00000165629	ENSG00000083937
Uniprot IDs		B4DL14 P36542 Q8TAS0	B2RE76 Q9UQN3
PDB IDs			2JQK
Enriched GO Terms of Interacting Partners?
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