PAN3 and SVIL

Data Source:
BioGRID (two hybrid)

		PAN3	SVIL
Description		poly(A) specific ribonuclease subunit PAN3	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	P-body Cytosol PAN Complex	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Protein Phosphorylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		Deadenylation of mRNA
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		4 interacting genes: PABPC1 PAN2 SVIL TNRC6B	35 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		255967	6840
HPRD ID		17818	04992
Ensembl ID		ENSG00000152520	ENSG00000197321
Uniprot IDs		Q58A45	A0A6I8PIX7 O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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