PAN3 and TNRC6B

Data Source:
BioGRID (affinity chromatography technology, pull down, proximity labelling technology)

		PAN3	TNRC6B
Description		poly(A) specific ribonuclease subunit PAN3	trinucleotide repeat containing adaptor 6B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Cytosol PAN Complex	P-body Nucleoplasm Cytosol
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Protein Phosphorylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways		Deadenylation of mRNA	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)	Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Breast size ( 29855537) Chronotype ( 26955885 30696823) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hand grip strength ( 25637336) Height ( 19570815) Immature fraction of reticulocytes ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mammographic density (dense area) ( 25342443) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Meat-related diet ( 32066663) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 23065704 19117981) Pulse pressure ( 27841878 27618447 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618447) Uterine fibroids ( 21460842 31488892 31249589 30194396 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		4 interacting genes: PABPC1 PAN2 SVIL TNRC6B	3 interacting genes: AGO4 PAN3 UBQLN4
Entrez ID		255967	23112
HPRD ID		17818	10021
Ensembl ID		ENSG00000152520	ENSG00000100354
Uniprot IDs		Q58A45	A0A024R1N5 Q9UPQ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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